Impact of the structure-activity relationship of AHL analogues on quorum sensing in Gram-negative bacteria

Christiane Chbib

doi:10.1016/j.bmc.2019.115282

Impact of the structure-activity relationship of AHL analogues on quorum sensing in Gram-negative bacteria

Bioorg Med Chem. 2020 Feb 1;28(3):115282. doi: 10.1016/j.bmc.2019.115282. Epub 2019 Dec 28.

Author

Christiane Chbib¹

Affiliation

¹ College of Pharmacy, Larkin University, 18301 North Miami Ave, Miami, FL 33169, United States. Electronic address: cchbib@ularkin.org.

PMID: 31918952
DOI: 10.1016/j.bmc.2019.115282

Abstract

With the emergence of microbial resistance pathogens, recent research aims at studying new mechanisms of action of antibiotics. This review discusses the mechanisms and types of quorum sensing (QS) inhibitors in Gram negative bacteria. It illustrates all published data available in literature pertaining to novel compounds that showed activity against different targets in the quorum sensing pathways in Gram negative bacteria. A systemic overview has been conducted by searching PubMed, Medline, and the Cochrane Library and data extraction of all quorum sensing inhibitors with their mechanisms of action have been collected. This review will focus on signaling autoinducer AI-1 in Gram negative bacteria. The biological activity of the antagonists is mainly reported as IC₅₀ (the concentration of an inhibitor where the response is reduced by half).

Keywords: Acyl homoserine lactone (AHL); Gram negative bacteria; Quorum sensing; Structure activity relationship.

Publication types

Review

MeSH terms

Acyl-Butyrolactones / chemistry
Acyl-Butyrolactones / pharmacology*
Animals
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology*
Gram-Negative Bacteria / drug effects*
Humans
Microbial Sensitivity Tests
Molecular Conformation
Quorum Sensing / drug effects
Structure-Activity Relationship

Substances

Acyl-Butyrolactones
Anti-Bacterial Agents